Back in the day when I was riding Hondas (CB-350 Four and later a CB-750F Super Sport), I never heard of anti-sieze and thus never used it. Since I had never had problems getting spark plugs out, I never even thought about it.
However, the one item that kept bugging me was that I was going to cross thread the plug as I screwed it in. Many, many years ago, I had done this with my Dad's "Lawn Boy" lawn mower. Back to the motorcycles: I used a short section of rubber hose, (fuel hose, I think) and slipped it over the end of the spark plug and turned the plug into the threads by twisting the fuel hose. The idea being the fuel hose would slip and not turn the spark plug if I had it going in with crossed threads. Now, I can't say for sure if this REALLY worked, but I've never cross threaded a spark plug when using the fuel hose.
By the way, the four or five inches of fuel line made a dandy extension for getting the plugs into the heads of the Honda motorcycles.
Ray Lovinggood
Carrboro, North Carolina, USA